Brain cells generate and propagate nerve impulses, or action potentials, by controlling the flow of positive sodium and potassium ions in and out of the cells. Re-establishing the ion equilibrium after an action potential requires energy. The amount of energy needed for action potentials was previously estimated using a giant nerve cell from squid. Now, researchers at the Max-Planck Institute for Brain Research in Germany show that squid cell studies overestimated the amount of energy necessary to generate an action potential by almost a factor of four, suggesting human brains have the same potential to be energy efficient. The researchers used a novel technique to record the voltage generated by nerve cells to show that a rather subtle separation between the timing of sodium entry and potassium exit during action potentials can determine how much energy is expended to maintain the ionic gradients, Murthy says. Murthy goes on to say that [these results] are important, not just for a basic understanding of brain metabolism, but also for interpreting signals detected by non-invasive brain imaging techniques. Sorensen concludes that the amazing thing is that we didn't realize the result a long time ago! -ENDS- Media Contact Steve Pogonowski Public Relations Manager Faculty of 1000 [email protected] http://blog.f1000.com http://twitter.com/f1000 http://youtube.com/Facultyof1000
Notes to Editors
1. Venkatesh Murthy, Faculty Member for F1000 Biology, is Professor of Molecular and Cellular Biology at Harvard University http://f1000biology.com/about/biography/1467388697212944
2. Jakob Sorensen, Faculty Member for Neuroscience, is Professor of Neuroscience at the Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark http://f1000biology.com/about/biography/9836154631995993
3. The full text of this article is available free for 90 days at http://www.f1000biology.com/article/t6pgnp2cs29949r/id/1164821.
4. An abstract for the paper, Energy-Efficient Action Potentials in Hippocampal Mossy Fibers by Alle, Roth and Geiger, is at
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